Microvascular dysfunction after myocardial ischemia
نویسندگان
چکیده
منابع مشابه
Transient myocardial ischemia during acetylcholine-induced coronary microvascular dysfunction documented by myocardial contrast echocardiography.
A 77-year-old white woman was referred for diagnostic coronary angiography after a 6-month history of exertional breathlessness and back pain. Her cardiovascular risk factors were hypercholesterolemia (low-density lipoprotein, 153 mg/dL) and a positive family history for cardiovascular disease (father died at 73 years of age because of a peripheral artery occlusive disease event). Furthermore, ...
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BACKGROUND AND PURPOSE Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral microvascular dysfunction, inflammation, and tissue injury induced by brain isch...
متن کاملAntagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia.
OBJECTIVES The goal of this study was to assess whether selectin blockade reduces myocardial platelet deposition and platelet-mediated injury after transient ischemia. BACKGROUND Selectins participate in platelet adhesion to reperfused endothelium. METHODS Thiopental-anesthetized, open-chest pigs were subjected to mechanical injury of the left anterior descending coronary artery followed by...
متن کاملNitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.
OBJECTIVES The purpose of this study was to test if nitric oxide (NO) could improve microvascular perfusion and decrease tissue injury in a porcine model of myocardial ischemia and reperfusion (I/R). BACKGROUND Inhaled NO is a selective pulmonary vasodilator with biologic effects in remote vascular beds. METHODS In 37 pigs, the midportion of the left anterior descending coronary artery was ...
متن کاملMyocardial Edema and Ischemia in Coronary Microvascular Embolization
Background. Oxygen-derived free radicals are thought to injure the ischemic heart during coronary microvascular embolization. Methods and Results. To test this idea, microspheres (15 gm in diameter) were repetitively administered into the left anterior descending coronary artery to cause microvascular embolization in dogs. Myocardial contractile and metabolic dysfunctions were significantly att...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1995
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(95)70313-6